Gisondo starred in the series Santa Clarita Diet as Eric Bemis in 2017. He has starred in or done voice work for the movies Jam, Air Buddies, Halloween, Walk Hard: The Dewey Cox Story, Snow Buddies, For Heaven’s Sake, Four Christmases, Space Buddies, Santa Buddies, Spooky Buddies, Treasure Buddies, The Three Stooges, The Amazing Spider-Man, The Amazing Spider-Man 2, Night at the Museum: Secret of the Tomb, Vacation, and Hard Sell. Gisondo has won Young Artist Awards for Spooky Buddies and The Bill Engvall Show.