Kizer played for the Browns in 2017 and the Green Bay Packers in 2018. He joined the Oakland Raiders in 2019. In 2017 he signed a four year deal with the Browns for $4.95 million with $2.42 million guaranteed and a signing bonus of $1.73 million. During his first two NFL seasons DeShone Kizer threw 11 touchdowns and 24 interceptions.