In 1986 she starred as Nancy Spungen in the movie Sid and Nancy. Webb also starred in the films Twins, Ghostbusters II, A Dangerous Woman, Love Affair, She’s So Lovely, The Newton Boys, Practical Magic, and Repo Chick. In 1989 she was nominated for a Primetime Emmy Award for Outstanding Guest Actress in a Drama Series for China Beach. She has also appeared in episodes of the TV series Judging Amy, House, Two and a Half Men, Medium, and CSI: Crime Scene Investigation.