In 2016 Kalyan starred as Otto Goodwin in the television series Second Chance. In 2009 he had a recurring role as Dr. Raj Paresh on the TV series Nip/Tuck. Kalyan has also starred in the movies Paul Blart: Mall Cop, Fired Up, Up in the Air, Youth in Revolt, High School, No Strings Attached, and Paul Blart: Mall Cop 2. Adhir married actress Emily Wilson in 2016.